Tuesday, 8th February The 47th Lorne Conference on Protein Structure and Function 2022

• Toward molecular simulations of the bacterial cell - Adrian H Elcock
• Harnessing Conformational Dynamics to Engineer New Enzymes - Lynn Kamerlin
• Fine-tuning the Spike: Role of the nature and topology of the glycan shield in the function of the SARS-CoV-2 S glycoprotein - Elisa Fadda

• Membrane permeabilisation is mediated by distinct epitopes in mouse and human orthologs of the necroptosis effector, MLKL - Chris R. Horne
• Electrodetection of small molecules by conformation-mediated signal enhancement - Adam M Damry
• Cryo-EM studies of replication origin activation - Jacob S Lewis
• Understanding ligand binding to adenosine receptors using cryo-EM - Alisa Glukhova
• Blocking malaria transmission with nanobodies - Melanie H. Dietrich
• Structural and functional analysis of target recognition by the lymphocyte adaptor protein LNK - Rhiannon Morris
• Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues - Ashleigh S Paparella
• Structure-function studies of regulatory factors controlling quorum sensing and horizontal gene transfer in nitrogen-fixing symbiotic bacteria - Joshua P Ramsay
• Insight into somatic angiotensin-1 converting enzyme structure and dynamics revealed by cryo-EM - Lizelle Lubbe

• Lipid modulation of neurotransmitter transporter function - Megan O'Mara
• Computational Tools to Help Understand and Map Protein-Protein Interactions - Carlos Rodrigues
• Dynamic drug targets: Using Cryo-EM data and MD simulations to create realistic 3D animations of GPCR complexes - Sarah J Piper
• structure and in-silico based protein engineering - Albert Ardevol
• Structural Basis of Rapid and Voltage Dependent Inactivation of HERG Potassium Channels - Carus Lau
• Harnessing RNA polymerase protein structure to predict drug resistance in tuberculosis and COVID-19 - Stephanie Portelli
• Disruption of water networks is the cause of human/mouse species selectivity in urokinase plasminogen activator (uPA) inhibitors derived from hexamethylene amiloride (HMA) - Haibo Yu

• Understanding the structural basis of TIR-domain assembly formation in TRAM- and TRIF- dependent TLR signalling - Mengqi Pan
• Novel Nucleic Acid Binding Properties of Human UVSSA: A Component Protein of Transcription Coupled DNA Repair Complex - Hiral Mistry
• Structural characterisation of ZrmB and its role in opine metallophore biosynthesis in Pseudomonas aeruginosa - Dalton H. Y. Ngu
• Characterising TIR-containing proteins from A. thaliana - Bryan Lim
• The role of activity-dependent phosphorylation in the presynaptic function of α-synuclein - Elysa M Carr
• Comfort eating: macropinocytosis as a resistance mechanism in breast cancer following glutamine transporter knockout - Natasha J Freidman
• A conserved cholesterol binding site modulates glycine transporter functionality and pharmacology - Zachary J Frangos
• The glycine transporter 2 allosteric inhibitor ORG25543 has different molecular determinants of potency and reversibility - Ryan Cantwell Chater
• Determining the role of the TIR domain of Interleukin-1 receptor 8 (SIGIRR) in regulating TLR4 signaling - Surekha Nimma
• Characterising unexpected interactions of a glutamine transporter inhibitor with members of the SLC1A transporter family - Chelsea Briot
• NAD⁺ nucleosidase activity and structure study of PumA and AbTIR - Sulin Li
• Structural basis of higher-order assembly formation in Toll-like receptor 1,2 and 6 signaling pathway - Yan Li
• Characterisation of nanobodies as a tool for studying Cavin1 protein  - Ya Gao
• IDENTIFICATION AND CHARACTERISATION OF LIPIDS THAT ARE POSITIVE ALLOSTERIC MODULATORS OF GLYCINE RECEPTORS - Casey I Gallagher
• Engineering Fast-Responding Protein Biosensors - Cagla Ergun Ayva
• The structure and function of novel Coxiella burnetii effector proteins - Cameron C Oppy
• The DNA binding protein RdfS; more than an excisionase - Callum J Verdonk
• Mechanistic basis for SNX27-Retromer coupling to ESCPE-1 in promoting endosomal cargo recycling - Qian Guo
• Structural and functional characterization of Full-Length MyD88 adaptor protein - Zannati Ferdous Zaoti
• Molecular insights into the recognition of lipid-based antigens by human Type II Natural Killer T cells - Kean Thai On Chan Yew Poa
• Investigation of the nature of recombinant insulin analogs' interaction with partner receptors using the SPR technique - Ewa Kobylska
• Study on the biological effect of metabolites derived from long-acting recombinant insulin analogs - Ewa Kobylska
• Molecular Basis of Chemokine Inhibition by Tick Evasins - Shankar Devkota
• Localisation of the Polycomb Repressive Deubiquitinase complex - Cameron J Reddington
• Role of the pseudo-enzyme COP10 in regulation of plant photomorphogenesis - Brittany J Drummond
• Characterisation of chemokine GPCRs signalling in monocytes using state-of-the-art phosphoproteomics approach - Rina Pokhrel
• Combination of cell surface biotinylation and carbonate wash with on-bead digestion for plasma membrane proteomics from colorectal cancer cells - Payal Barua
• Engineering of Evasins by Exchanging their N-termini Alters Chemokine Binding Selectivity - Pramod Aryal
• Characterization of the protein-protein interaction between p97 and its cofactors - Abolfazl Mirzadeh
• Computational analysis and characterization of cardiopathic mutations - Saba SI Iftkhar
• Structural Characterisation of the Nucleosome Remodelling and Deacetylase (NuRD) Complex Using integrative modelling, single particle analysis, and alphafold prediction - Matthew J Jackman
• Secretion of a unique lipoprotein through a TolC-like channel - Freya J Hodges
• Comparison of mammalian and avian SOCS1 highlights differences in stability and target affinity - Yuntong Wu
• Identification of novel genome organising factors using proximity labeling - Habib Francis
• NAD+ Metabolism in Wallerian Degeneration - Helen Y McGuinness
• Developing inhibitors against fungal inositol polyphosphate kinases (IPK) as a novel class of antifungal drug - Desmarini Desmarini
• The High Performance Macromolecular Crystallography (MX3) Beamline - Daniel Eriksson
• Structural basis of the citrullinated self-antigen-mediated T cell immunity - Jia Jia Lim
• Structural insights into the antifungal drug target, guanosine monophosphate synthase from Aspergillus fumigatus - Stephanie Nguyen
• Studies towards high-resolution imaging of ATP synthase in synthesis mode - Emily J Furlong
• Structural and functional characterisation of a plant innate immune receptor - Natsumi Maruta
• Allosteric regulation of SARM1, the executioner of axon degeneration - Weixi Gu
• Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses - Sofiya Tsimbalyuk
• Design of lipidic cubic phases for low temperature studies: implications for membrane protein reconstitution and crystallization - Livia Salvati Manni
• Toward better diagnostic of Parkinson’s Disease – putting a number on each α-synuclein aggregates - Derrick Lau
• Role of the SARS-CoV-2 nonstructural protein 9  - Dene R Littler
• Ataxia-linked SLC1A3 mutations alter EAAT1 chloride channel activity and glial regulation of CNS function - Qianyi Wu
• Structural and functional characterisation of AAA+ ATPase p97 protein homologs in Plasmodium falciparum - George Kobakhidze
• Characterization of Structure and Function of Inducible HSP70 in an Antarctic Yeast, Glaciozyma antarctica PI12, in Response to Thermal Stress - Nur Athirah Yusof
• The HIV Capsid can access the Nuclear Pore Complex through interactions with FG motifs - Claire F Dickson
• The HIV Capsid acts as a karyopherin to enter the nucleus - Sophie Hertel
• Structure-guided Engineering of Tick Evasin to Enable Targeting Chemokines in Inflammatory Diseases - Ram Prasad BHUSAL
• Structural mapping of the PEAK pesudokinase interactome identifies a molecular switch regulating PEAK3/CrkII signalling - Michael J Roy
• Structure and function of fungal and plant acetohydroxyacid synthases - Yu Shang Low
• Structural and functional characterization of an exported plasmodial J domain protein, PFE0055c and its specific interactions with PfHsp70-x   - Tanima Dutta
• mmCSM-NA: accurately predicting effects of single and multiple mutations on protein‒nucleic acid binding affinity - Thanh Binh Nguyen
• Higher Sensitivity, Data Quality and Throughput for Hydrogen Deuterium Exchange Experiments with Extended Ion Mobility Separation - Heather Patsiouras
• Improved Coverage of Glycoprotein Using Pressurised Online Pepsin Digestion for HDX-MS - Caryn Hepburn
• Utilisation of Cyclic Ion Mobility with multiple pass acquisition for the analysis of glycopeptides and glycoforms associated with SARS-CoV-2 - Caryn Hepburn
• Structure-function analysis of the TLR4 signalosome at a single cell level - Timothy W Muusse
• Single-molecule live-cell imaging: investigating the role of DNA polymerase IV in the repair of single-stranded DNA gaps in Escherichia coli - Ouraida Amira Belhaffef
• Cryo-EM and crosslinking studies of the BAK: VDAC2 complex in apoptosis - Zheng Yuan
• Plamodium falciparum tyrosyl-tRNA synthetase as an antimalarial drug target - Chiawei Tai
• Arginine-rich C9orf72 ALS proteins stall ribosomes in a manner distinct from canonical ribosome-associated quality control substrates - Viacheslav Kriachkov
• Towards a structural understanding of drug transport in the SLC22 family - Yi C Zeng

Chairs: Charlie Bond & Lakshmi Wijeyewickrema

• Multiscale simulation of enzyme catalytic mechanisms: dynamics, evolution and design - Adrian Mulholland
• Approximating the nucleoli with proteins and RNA: shaping condensate dynamics with ATP:Mg²⁺ - N. Amy Yewdall
• Machineries and Supercomplexes in Cellular Quality Control and Adaptive Immunity - Robert Tampé

EMBO Keynote Lecture - Robert Tampé