Monday, 7th February The 47th Lorne Conference on Protein Structure and Function 2022

• Super-Trafficking of an Ion Channel as a Disease Mechanism - Charles Sanders
•  ‘Periscope Proteins’ at the host:microbe interface - Fiona Whelan
• Structural basis of chain-type specificity and regulation of the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216 - Bernhard C. Lechtenberg
• Stochastic mechanisms in membrane organization and curvature - Jeanne Stachowiak

Protein Society Speaker: Charles Sanders

• Trapping and visualization of outer membrane protein folding intermediates - Jian Payandeh
• Autoinhibition of the RAS master regulator neurofibromin revealed using cryo-EM - Andrew M Ellisdon
• Improving safety and efficacy of chimeric antigen receptor (CAR)-T cell therapies - Ashleigh Davey
• High-resolution structures of infectious mammalian prions - Allison Kraus

• Modulation of Mycobacterium tuberculosis isocitrate lyase activities - Brooke Kwai
• Resolving stalled replication forks in Escherichia coli at sites of nucleoprotein complexes - Kelsey S Whinn
• Linking the functionality of glyoxalase 1 to the changes in its structure - Alexandra Dimitropoulos
• Ancestral sequence reconstruction reveals highly thermostable ancestral PETase for efficient PET degradation - Yvonne Joho
• Development of a biologically thermostable glutamine FRET biosensor - Skye Young
• Illuminating the chemical space for MR1-restricted ligands: a binding assay using fluorescence polarisation - Carl J. H. Wang
• Cross-reactivity of CD4+ gluten-reactive TCRs in Celiac Disease - Laura Ciacchi
• CD4⁺ T cell recognition of pneumolysin, a pore-forming cytolysin derived from Streptococcus pneumoniae presented by a common HLA allotype - Lisa Ciacchi
• Enzyme dynamics during lesion bypass at the E. coli  replication fork  - Gurleen Kaur
• Unravelling the molecular architecture of the Commander assembly - Michael D Healy
• Peptide-based inhibitors for targeting telomerase-active cancers - Reginald Young
• Physicochemical Properties of Ionic Liquids and their Effect on Proteins - Stuart Brown
• Structural characterisation of influenza epitopes presented by a prevalent Indigenous Australian Human Leukocyte Antigen - Andrea T Nguyen
• Rapid single-molecule characterisation of nucleic-acid enzymes - Stefan Mueller
• Structural and functional characterisation of Huc, a high affinity hydrogenase from Mycobacterium smegmatis - Ashleigh Kropp
• DNA Polymerase II and the beta clamp: is the beta clamp required for TLS recruitment? - Thomas J Armstrong
• Understanding and exploiting Mycobacterial cholesterol metabolism: a potential therapeutic target in Mycobacteria - Amna Ghith
• A cryo-EM structure of the human A₃ adenosine receptor bound to the endogenous agonist adenosine - Liudi Zhang
• The hunt for the elusive S-lignin O-demethylase - Alix Harlington
• Probing structure-activity relationships of cannabinoid receptor type 1 ligands with cryo-EM - Kieran Deane-Alder
• Investigation of the structural and functional properties of the P2X1-purinoceptor for use in male contraception - Felix M. Bennetts
• Molecular evolution of ligand specificity by thermodynamic adaptation in LacI transcriptional regulators  - Hannah Bott
• The Application of Peroxygenase P450 Enzymes as Selective Oxidation Catalysts - Jinia Akter
• PALI1 is a physical bridge between two master-regulator histone methyltransferase complexes - Melanie Murray
• Investigation of the Mediator Complex in Ceanorhabditis elegans. - Joanne Coyle
• Disrupting DNA double-strand break repair sensitises bacteria to antibiotics and may slow the evolution of resistance - Elizabeth K Wright
• Structure of xanomeline bound M₄ muscarinic acetylcholine reveals an unexpected dual orthosteric and allosteric binding profile - Wessel A. C. Burger
• Agonist-bound GPR52 G protein complex structures solved by cryo-EM - Yao Lu
• Biochemical study of HOIL-1L, an unconventional RING-between-RING (RBR) E3 ubiquitin ligase - Xiangyi Susie Wang
• Toward a structural understanding of amylin receptor phenotype: implications for therapeutic development for obesity - Jian-Jun Cao
• Native purification and structural characterisation of a mycobacterial carbon monoxide dehydrogenase - David L Gillett
• Defining the role of the RBR E3 ligase RNF14 as a transcriptional coactivator - Sarah Trevelyan
• Human MLKL is maintained by RIPK3 in an inactive conformation prior to disengagement and cell death by necroptosis - Yanxiang Meng
• Rational antibody affinity maturation using graph-based signature - Yoochan Myung
• Enzymes and Bleach: Engineering Cytochrome P450 Peroxygenases for Fine Chemical Synthesis - Joel Lee
• Determining the structural and biochemical basis for heme acquisition by Hgp2, a haemoglobin-haptoglobin binding transporter from Haemophilus influenzae - Daniel R Fox
• Characterising a novel Type VI DNase effector and immunity protein pair from Acinetobacter baumannii - Brooke K Hayes
• Mycobacterial P450 enzymes as potential therapeutic targets - Daniel Z Doherty
• Functional biomolecular condensates implicated in parasite antigen trafficking of malaria-infected red blood cells - Olivia M. S. Carmo
• ATP disrupts lipid binding equilibrium to drive retrograde transport critical for bacterial outer membrane asymmetry - Wen-Yi Low
• Molecular insights into the HLA-B35 molecules’ classification associated with HIV control - Christian A Lobos
• Structure and dynamics of the pituitary adenylate cyclase-activating polypeptide 1 receptor (PAC1R)   - Theodore J Nettleton
• Activation mechanism of PINK1 - Zhong Yan Gan
• Bacterial competition between prominent gut microbial species is mediated by a bacterial toxin with a novel structural fold - Bronte A Johnstone
• Computational design and experimental characterisation of a stable human heparanase variant - Cassidy Whitefield
• Investigating how the EphB6 pseudokinase mediates cell-cell communication using Cryo-ET - Lung-Yu Liang
• Structural studies of granulocyte colony stimulating factor and its receptor - Kaiseal Sarson-Lawrence
• Half a century after its discovery, the cryo-EM structure of Erf annealase of phage P22 provides insights into its evolution and molecular mechanisms - MariaKatarina Lambourne
• Towards the development of herbicides targeting lysine biosynthesis - Emily R. R. Mackie
• Fab-ulous insights into Acinetobacter baumannii fatty acid synthesis reductases - Emily M Cross
• Structural insight into the PALS1 PDZ1 domain interaction with SARS-CoV-1 and SARS-CoV-2 E protein - Airah Javorsky
• Priming Sunflower Trypsin Inhibitor as a potent inhibitor of Kallikrein 8 - Alex Duff
• Identification of bikunin as a scaffold for a humanised aprotinin analogue using molecular dynamics simulations - Alex Jackson
• Structural characterization of the porcine adeno-associated virus Po1 capsid protein binding to the nuclear trafficking protein importin alpha - Mikayla Hoad
• MERS-CoV ORF4b EMPLOYS AN UNUSUAL BINDING MECHANISM TO TARGET IMPα AND BLOCK INNATE IMMUNITY - Thilini S Munasinghe
• Smaller tagging strategies for proximity-based labeling interactors of proteins   - Ruohua Lyu
• The mitochondrial pyruvate carrier (MPC) complex mediates one of three pyruvate-supplying pathways that sustain Arabidopsis respiratory metabolism - Xuyen Le
• THE MOLECULAR MODE OF ACTION FOR RESTORER-OF-FERTILITY-LIKE PROTEINS IN PLANT MITOCHONDRIA - Sang Huynh
• Structural characterization of a Type B chloramphenicol acetyltransferase from the emerging pathogen Elizabethkingia anophelis NUHP1 and screening for a potential inhibitor using a molecular docking approach - Seyedmohammad Ghafoori
• Does the Dimerization of IFNAR2 improve its affinity for JAK1 FERM-SH2? - Amarachi Amah
• Structural studies of the active state assembly and inhibition mechanism of SARM1-TIR domain - Forhad K Saikot
• Structural characterization of SARS-Cov-2 spike derived peptides presented by the Human Leukocyte Antigen A*29:02. - Lawton LM Murdolo
• Membrane solubilisation by tuneable polymer nanodiscs - Michelle D Farrelly
• Protein-Level Regulation of Isocitrate Lyase in Mycobacterium tuberculosis - Evelyn Huang
• Discovery of RIPK3 RHIM-binding peptides for the modulation of necroptosis, using RaPID cyclic peptide screening. - Jessica A Buchanan
• Pore structure controls stability and molecular flux in engineered cages - Lachlan S.R. Adamson
• Crystal structure of a complex between the electron-transfer partners arsenite oxidase and cytochrome c₅₅₂, from the arsenite respiring bacterium Pseudorhizobium banfieldii str. NT-26. - Nilakhi Poddar
• Characterization of novel proteins secreted by Campylobacter jejuni - relevance to colonisation in chickens - Debolina Majumdar
• Developing novel small molecule ligands of TDP-43 - Hei Wun Alison Cheng
• Playing by their own rules – viral M45 protein employs a large interaction interface to inhibit host necroptosis - Nikhil R Varghese
• Characterisation of the essential histidine kinase walk from staphylococucs aureus - Navneet Kaur

• Structure and function of designer RNA editing factors - Santana Royan
• Unravelling the features of T cell Response to a dominant HLA B57-Restricted Gag epitope in HIV⁺ Controllers and non-Controllers. - Dimitra SM Chatzileontiadou
• SCIMP is a spatiotemporal transmembrane scaffold for Erk1/2 to direct pro-inflammatory signaling in TLR-activated macrophages   - Lin Luo
• Structural mechanism of SARS-CoV-2 entry and activation of spike glycoprotein by engaging unique host factors and potential antiviral interventions - Naveen Vankadari
• How do BAK monomers convert from inert monomers into membrane rupturing BAK dimers? - Richard W Birkinshaw
• Solvent effects of protic ionic liquids on proteins - Tamar Greaves
• Pore structure controls stability and molecular flux in engineered protein cages - Yu Heng Lau
• Structural insights into oligomeric states of 12-lipoxygenase: a novel drug target for thrombosis - Alisa Glukhova
• Structural characterisation of peptide activated class A G protein coupled receptors - Jesse I Mobbs
• SAXS Investigation of Solvent Effect on Globular Proteins - QI (Hank) Han
• Structural analysis of In vitro evolution of antibiotic resistance to oxazolidinone antibiotics in Staphylococcus aureus - Matthew Belousoff
• Structure and function of GPR88, an orphan GPCR target in psychiatric disorders - Natalie A Diepenhorst
• Targeting the circumsporozoite protein of Plasmodium falciparum - Joe A Kaczmarski
• Using nanobodies for drug delivery across the Blood Brain Barrier - Gabby Watson
• Prolonged signaling of backbone-modified glucagon‐like peptide‐1 analogues with diverse receptor trafficking - Brian P Cary
• Key role for the α1-α2 loop in restraining BAK activation identified from the structure of BAK bound to activating antibody 7D10 - Michelle S Miller
• Visualising bacterial toxin delivery machines in situ - Debnath Ghosal
• Rational Expression - Larissa Doughty
• Development of nanobody therapeutics against human coronaviruses - Lynn Tan
• Internal structure of biomolecular condensates - Yi Shen
• Disulfide bond formation between T-cell receptor and peptide antigen lowers the threshold of T cell activation - Christopher Szeto
• Novel structures in the SNX-RGS proteins revealed by AlphaFold2 suggest a new class of lipid transfer domain - Brett Collins
• Structural basis for antagonism of IGF1R by a viral insulin-like peptide - Nicholas S Kirk
• Towards the Development of Lyase Specific Inhibitors of Cytochrome P450 17A1. - Paul D O'Leary
• Structural insights into GLP-1R activation and allosteric modulation by non-peptidic ligands - Xin Zhang
• The role of the helicase in DNA replication: A single-molecule study - Richard R Spinks
• Understanding the molecular recognition of Bacteroides fragilis glycosphingolipids by type I Natural Killer T-cell receptor - Praveena Thirunavukkarasu
• Two novel structures of human RIPK3, in complex with necroptosis effector protein MLKL and kinase inhibitors - Katherine A Davies
• Structural insights into the ferroxidase and iron sequestration mechanisms of ferritin from Caenorhabditis elegans - Tess R Malcolm
• The transmembrane organisation of the B cell antigen receptor - Samyuktha Ramesh
• A Highly Conserved CD28 Transmembrane Motif Drives CAR-induced Cytokine Secretion - Nicholas Chandler
• Room-temperature serial snapshot micro-crystallography: highlights from XFELs and prospects at the Australian Synchrotron - Nadia Zatsepin
• Efficient Novel Protein Structure Determination using Iodinated and Brominated Ligands with Random Microseed Matrix Screening - Jia Truong
• Cryo-EM structural studies of the SLC4 transporters and GPCRs  - Yan Jiang
• Structural, Biochemical and Functional characterization of Salmonella BcfH: an unusual Dsb-like fimbrial protein - Pramod Dr Subedi
• nsSNPs in the ACE2 receptor: Analysis of polymorphisms in Asian, European and African populations - Alejandro A Gutiérrez-Hernández
• Development of inhibitors targeting vaccinia virus membrane assembly - Bishwa P. Subedi
• A biosensor to gauge protein homeostasis resilience differences in the nucleus compared to cytosol of mammalian cells   - Christian Makhoul
• Decoding the molecular mechanisms of inappropriate protein aggregation - Chloe A N Gerak
• Encapsulins as synthetic organelles for improved carbon fixation - Taylor N Szyszka
• Mitochondrial COA7 is a heme-binding protein with disulfide reductase activity, which acts in the early stages of complex IV assembly. - Shadi Maghool
• Unravelling protein function through deep mutational scanning - Margareta Go