The nucleosome remodelling and deacetylase (NuRD) complex regulates processes important to the epigenetic state of metazoan organisms, ranging from DNA repair to cell differentiation. There is little structural information about the intact complex, however, with most information limited to subcomplexes and structures of the functional domains of its subunits. This project attempts to determine a structure of the intact NuRD complex using single particle electron microscopy, a process that involves optimisation of sample preparation and imaging conditions prior to single particle analysis. Currently maps representing negatively-stained models of NuRD, NuDe (lacking the CHD4 subunit), and MHR (the core deacetylase module of NuRD) from HEK293 and MEL cells, or reconstituted from recombinant components - have been obtained using single particle analysis. Combining these with additional information obtained from crystal structures, chemical-crosslinking mass spectrometry and integrative modelling has allowed for the development of ensemble models that describe the overall architecture of the NuRD complex. Future efforts are now focused on validating these models by optimising approaches to cryo-electron microscopy analysis of these complexes; preliminary efforts in this regard will also be presented.